abstract：OBJECTIVE:The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail. METHODS:Human MSCs were isolated and cultivated onto the surface of a 3 x 3 mm porcine collagen I / III carrier. After incubation, cell cultur...

journal_title：European journal of medical research

authors： Zilkens C,Lögters T,Bittersohl B,Krauspe R,Lensing-Höhn S,Jäger M

更新日期：2010-01-29 00:00:00

abstract：BACKGROUND:The concept of total mesorectal excision has revolutionised rectal cancer surgery. TME reduces the rate of local recurrence and tumour associated mortality. However, in clinical trials only 50% of the removed rectal tumours have an optimal TME quality. PATIENTS:During a period of 36 months we performed 103 ...

journal_title：European journal of medical research

authors： Herzog T,Belyaev O,Chromik AM,Weyhe D,Mueller CA,Munding J,Tannapfel A,Uhl W,Seelig MH

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:In utero and/or childhood environmental tobacco smoke exposure is well known to adversely affect lung function and to depreciate child's health in many ways. Fewer studies have assessed the long-term effects on COPD development and disease severity in later adulthood. METHODS:COPD patients were interviewe...

journal_title：European journal of medical research

authors： Beyer D,Mitfessel H,Gillissen A

更新日期：2009-12-07 00:00:00

abstract：:In the treatment of pulmonary diseases the inhalation of aerosols plays a key role - it is the preferred route of drug delivery in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. But, in contrast to oral and intravenous administration drug delivery to the lungs is controlled by additional par...

journal_title：European journal of medical research

authors： Fischer A,Stegemann J,Scheuch G,Siekmeier R

更新日期：2009-12-07 00:00:00

abstract：OBJECTIVE:Oxygen therapy is used for the treatment of various diseases, but prolonged exposure to high concentrations of O(2) is also associated with formation of free radicals and oxidative damage. METHODS:In the present study we compared alpha-ketoglutarate dehydrogenase (KGDH) activity and mitochondrial oxidative d...

journal_title：European journal of medical research

authors： Kaplan P,Tatarkova Z,Engler I,Calkovska A,Mokra D,Drgova A,Kovalska M,Lehotsky J,Dobrota D

更新日期：2009-12-07 00:00:00

abstract：OBJECTIVE:It has recently been described that circulatory and BAL regulatory T-cells (Tregs), defined as CD4+CD25highCD127low are increased in patients with active sarcoidosis compared with other interstitial lung diseases. MATERIAL AND METHODS:We studied prospectively 17 patients (10 women, 7 men) of median age 39 ye...

journal_title：European journal of medical research

authors： Mroz RM,Korniluk M,Stasiak-Barmuta A,Ossolinska M,Chyczewska E

更新日期：2009-12-07 00:00:00

abstract：:The European Directive 98/79/EC on in vitro diagnostic medical devices (IVD) stipulates the marketing and post market surveillance of IVD in the European Economic Area. In cases of issues and field corrective actions, the manufacturers have to inform the responsible Competent Authorities (CA). In Germany, the Federal ...

journal_title：European journal of medical research

authors： Siekmeier R,Halbauer J,Mientus W,Wetzel D

更新日期：2009-12-07 00:00:00

abstract：BACKGROUND:Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. - OBJECTIVE:The aim of study was to determine the blood levels of sTM in patients with PR3-ANCA-as...

journal_title：European journal of medical research

authors： Zycinska K,Wardyn KA,Zielonka TM,Krupa R,Lukas W

更新日期：2009-12-07 00:00:00

abstract：:The introduction of integrase inhibitors as a new drug class for treatment of HIV have added a very potent and extremely well tolerated new treatment option to the HIV-armentarium. Particularly in patients with previously developed drug resistance, the availability of new active drugs offers great hope. Moreover, the ...

journal_title：European journal of medical research

authors： Rockstroh JK

更新日期：2009-11-24 00:00:00

abstract：:Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of ...

journal_title：European journal of medical research

authors： Sweeney L,Voelkel NF

更新日期：2009-09-28 00:00:00

abstract：:The Gasperini syndrome is a very rare brainstem disease characterized by the typical combination of ipsilateral lesions of the cranial nerves V-VII and dissociated contralateral hemihypesthesia, whereas both contralateral and ipsilateral hypacusis was described. Since the first description in 1912, only a few cases of...

journal_title：European journal of medical research

authors： Krasnianski M,Müller T,Zierz S,Winterholler M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure and thereby entails higher morbidity and mortality in trauma patients. Pro- and anti-inflammator...

journal_title：European journal of medical research

authors： Bogner V,Keil L,Kanz KG,Kirchhoff C,Leidel BA,Mutschler W,Biberthaler P

更新日期：2009-07-22 00:00:00

abstract：OBJECTIVES:Several epidemiological studies address psychosomatic self regulation as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and recognized to be associated with better survival of cancer patients, it is unclear what the self regulati...

journal_title：European journal of medical research

authors： Büssing A,Girke M,Heckmann C,Schad F,Ostermann T,Kröz M

更新日期：2009-05-14 00:00:00

abstract：OBJECTIVE:We intended to determine the reliability of a brief life satisfaction scale in a sample of patients with chronic diseases, and to analyze its external validity. METHODS:Reliability and factor analysis of the 8-item "Brief Multidimensional Life Satisfaction Scale" (BMLSS) were performed according to standard ...

journal_title：European journal of medical research

authors： Büssing A,Fischer J,Haller A,Heusser P,Ostermann T,Matthiessen PF

更新日期：2009-04-16 00:00:00

abstract：:The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to deter...

journal_title：European journal of medical research

authors： Heringlake M,Kox T,Poeling J,Klaus S,Hanke T,Franz N,Eberhardt F,Heinze H,Armbruster FP,Bahlmann L

更新日期：2009-03-17 00:00:00

abstract：:The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here...

journal_title：European journal of medical research

authors： Boban A,Radman I,Zadro R,Dubravcic K,Maretic T,Civljak R,Lisic M,Begovac J

更新日期：2009-01-28 00:00:00

abstract：INTRODUCTION:Carcinoma of the collecting ducts of Bellini of the kidney (CDC) is very rare but among the most aggressive urological entities. Standard therapy is not well defined with questionable efficacy. METHODS:We present two cases of male patients (49 and 66 years old) with pT3a pN2 CDC treated with a combination...

journal_title：European journal of medical research

authors： Staehler M,Haseke N,Schöppler G,Stadler T,Karl A,Siebels M,Ihrler S,Stief CG

更新日期：2008-11-24 00:00:00

abstract：:Progressive infantile spastic tetraparesis spans a wide spectrum of partially rare differential diagnoses. Based on a clinical example the differential diagnostic thoughts are discussed in detail. Though juvenile motor neuron disease is a rare entity, it has to be kept in mind for differential diagnostics in cases of ...

journal_title：European journal of medical research

authors： Kühnlein P,Sperfeld AD,Gdynia HJ

更新日期：2008-10-27 00:00:00

abstract：:Coronary angiograms performed at the time of an acute coronary syndrome typically present vessel occlusions, ruptured plaques or thrombotic lesions that require reperfusion therapy. However, occasionally, no coronary artery stenoses are detected. Myocardial ischemia frequently causes left ventricular wall motion abnor...

journal_title：European journal of medical research

authors： Germing A,Ulrich S,Fadgyas T,Grewe P,Mügge A,Lindstaedt M

更新日期：2008-08-18 00:00:00

abstract：:Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease. After electromyography demonstrated myopathic changes, a skeletal muscle biopsy was performed showing histological signs of granulomatous myositis. In extensive diagnostic workup underlying primary granu...

journal_title：European journal of medical research

authors： Gdynia HJ,Osterfeld N,Dorst J,Ludolph AC,von Arnim CA,Sperfeld AD

更新日期：2008-07-28 00:00:00

abstract：:The prevalence of high plasmatic levels of homocysteine in hypertensive patients with mild renal dysfunction (MRD) defined by 2003 European Hypertension Society Guidelines (men plasmatic creatinine between 1.3 and 1.5; women plasmatic creatinine between 1.2 and 1.4 mg/dl) has not been previously reported. To evaluate ...

journal_title：European journal of medical research

authors： Robles NR,Sanchez Munoz-Torrero JF,Garcia Gallego F,Velasco Gemio J,Escola JM

更新日期：2008-05-26 00:00:00

abstract：AIM:We have investigated CsA induced liver hyperplasia to explore the potential effects on the immunogenicity of the regenerating liver within the clinical context of rejection after transplantation. MATERIALS AND METHODS:Flow cytometry analysis of hepatocytes, isolated 48 hours after 2/3 partial hepatectomy (PH2/3) o...

journal_title：European journal of medical research

authors： Fouzas I,Daoudaki M,Sotiropoulos GC,Vrochides D,Papanikolaou V,Imvrios G,Sgourakis G,Molmenti EP,Vavatsi N,Thalhammer T,Takoudas D,Broelsch CE

更新日期：2008-04-30 00:00:00

abstract：:Bacteremia due to Capnocytophaga sputigena occurred in a 4-year and 9-month-old Japanese girl patient with acute erythroblastic leukemia in Shinshu University Hospital, Japan. On her admission to the hospital, she had a temperature of 38.2 degrees C with canker sore. Prior to the commencement of chemotherapy, peripher...

journal_title：European journal of medical research

authors： Matsumoto T,Matsubara M,Oana K,Kasuga E,Suzuki T,Hidaka E,Shigemura T,Yamauchi K,Honda T,Ota H,Kawakami Y

更新日期：2008-03-31 00:00:00

abstract：:We investigated the expression pattern of Jagged1 peptide in mandibular condylar cartilage, as a type of secondary cartilage. Mandibular condyle of ddY mice were fixed from embryonic day 15 (E15) through just after birth (equivalent to E19). Serial sections were examined using histological immunohistochemical (IHC) te...

journal_title：European journal of medical research

authors： Shimizu T,Okafuji N,Nakano K,Kurihara S,Kawakami T

更新日期：2008-01-23 00:00:00

abstract：:Among primary hepatic malignancies, sarcomas represent a minority of 2 %. Of those, primary hepatic angiosarcoma is the most common one. In the past its incidence has been related to the exposure of certain chemicals like thorotrast, vinyl-chloride or arsenic. - Patients suffering from this aggressive, highly vascular...

journal_title：European journal of medical research

authors： Matthaei H,Boelke E,Eisenberger CF,Alldinger I,Krieg A,Schmelzle M,Poremba C,Schellhammer F,Knoefel WT,Budach W,Peiper M

更新日期：2007-12-14 00:00:00

abstract：OBJECTIVE:Changes in therapeutic concepts can only be justified by a significant improvement of outcome parameters. Furthermore, detailed statistics of complications are needed to guarantee high quality of treatment. This study describes the new University of Munich Lung Cancer Group Database. METHODS:The MLCG-Databas...

journal_title：European journal of medical research

authors： Kühnl A,Hocaoglu Y,Herzog M,Schmidt M,Hornung HM,Jauch KW,Hatz R,Graeb C

更新日期：2007-10-30 00:00:00

abstract：:CCR5 receptor inhibitors are currently being introduced into clinical practice. In some instances treatment failure is related to the selection of pre-existing CXCR4-tropic minority virus strains. Up to date it is unclear whether the outgrowth of a CXCR4 using reservoir is associated with accelerated HIV-disease. In a...

journal_title：European journal of medical research

authors： Arastéh K,Stocker H

更新日期：2007-10-15 00:00:00

abstract：:Drug development in the field of HIV treatment is rapid. New nucleoside analogues (NRTI), non-nucleoside analogue reverse transcriptase inhibitors (NNRTI), and protease inhibitors (PI) are currently being investigated in human trials. Furthermore, inhibitors of HIV attachment, fusion and integrase with novel modes of ...

journal_title：European journal of medical research

authors： Stellbrink HJ

更新日期：2007-10-15 00:00:00

abstract：OBJECTIVE:To report on radiological and epidemiological characteristics of pulmonary disease in patients with HIV infection in times of highly active antiretroviral therapy (HAART). METHODS:Clinical data of 130 HIV infected adults with acute pulmonary symptoms were compared with findings in chest radiography (n = 130)...

journal_title：European journal of medical research

authors： Schlossbauer T,Schmidt GP,Bogner JR,Sing A,Reiser MF,Becker-Gaab C

更新日期：2007-08-16 00:00:00

abstract：OBJECTIVE:To compare two reduced dose indinavir (IDV) + ritonavir (RTV) combinations guided by therapeutic drug monitoring (TDM) in treatment-naive HIV1-infected patients. METHODS:HIV1-infected treatment naive patients were prospectively randomized to treatment with IDV 600 mg or 400 mg BID each in combination with RT...

journal_title：European journal of medical research

authors： Wasmuth JC,Rodermann E,Voigt E,Vogel M,Lauenroth-Mai E,Jessen A,Burger D,Rockstroh JK

更新日期：2007-07-26 00:00:00

abstract：:The purpose of the present study was to evaluate clinically the effect of an anaesthetic gel (lidocaine 20 mg/g as active agent) on pain sensitivity and early wound healing following nonsurgical periodontal therapy. A total of 40 patients with chronic periodontitis were enrolled in this randomized, split-mouth, double...

journal_title：European journal of medical research

authors： Kasaj A,Heib A,Willershausen B

更新日期：2007-05-29 00:00:00

abstract：PURPOSE:Evaluation of MR-guided interstitial laser thermotherapy (ILT) of colorectal liver metastases under consideration of efficacy, safety and patient survival. MATERIALS AND METHODS:Sixty-six inoperable patients with a total of 117 colorectal liver metastases were treated with MR-guided laser therapy in 96 session...

journal_title：European journal of medical research

authors： Pech M,Wieners G,Freund T,Dudeck O,Fischbach F,Ricke J,Seemann MD

更新日期：2007-04-26 00:00:00

abstract：BACKGROUND:During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. ...

journal_title：European journal of medical research

authors： Kupfer B,Simon A,Jonassen CM,Viazov S,Ditt V,Tillmann RL,Müller A,Matz B,Schildgen O

更新日期：2007-03-26 00:00:00

abstract：OBJECTIVE:Identification of specific origin of lipid accumulation in the liver of patients with non-alcoholic fatty liver disease (NAFLD) is the most important step in preventing this condition. Because liver steatosis, in the obese patients without any systemic disease, can be graded easily by ultrasonography (US), we...

journal_title：European journal of medical research

authors： Fenkci S,Rota S,Sabir N,Akdag B

更新日期：2007-02-26 00:00:00

abstract：:To investigate Candida epidemiology and immunologic correlates of protection in HIV-1 infected patients, we analyzed oral Candida colonization in correlation to the Candida-specific T-cell response measured by g-IFN ELISPOT using different Candida (C.) albicans strains. In 16/46 patients (13 asymptomatic, 3 with oral ...

journal_title：European journal of medical research

authors： Bäuerle M,Schröppel K,Taylor B,Bergmann S,Schmitt-Haendle M,Harrer T

更新日期：2006-11-30 00:00:00

abstract：BACKGROUND:International guidelines for the treatment of HIV-1 infected children recommend efavirenz plus nucleoside reverse transcriptase inhibitor combination therapy for first line therapy. Until now little is known about the steady state pharmacokinetics of efavirenz in children. METHODS:11 HIV-1 infected children...

journal_title：European journal of medical research

authors： von Hentig N,Koenigs C,Elanjikal S,Linde R,Dunsch D,Kreuz W,Funk MB

更新日期：2006-09-29 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of composite extracts in reducing weight, as the main outcome measure. Secondary measures of the study were body composition change. DESIGN:Randomised, double blind, placebo-controlled clinical trial. SETTING:Tertiary university clinic. SUBJECTS...

journal_title：European journal of medical research

authors： Opala T,Rzymski P,Pischel I,Wilczak M,Wozniak J

更新日期：2006-08-30 00:00:00

abstract：BACKGROUND:The immunological and clinical benefits of structured treatment interruptions (STIs) during primary HIV-1 infection remain largely unclear. PATIENTS AND METHODS:Eight patients identified during primary HIV-1 infection were immediately treated with HAART and underwent subsequent STIs after reaching complete ...

journal_title：European journal of medical research

authors： Vogel M,Lichterfeld M,Kaufmann DE,Mui SK,Altfeld M,Voigt E,Ahlenstiel G,Kupfer B,Walker B,Spengler U,Rockstroh JK

更新日期：2006-07-31 00:00:00

abstract：BACKGROUND:Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. MATERIAL AND METHODS:In a retrospective case series, 5 patients with acute TBE were evaluated for clinic...

journal_title：European journal of medical research

authors： Kleiter I,Steinbrecher A,Flügel D,Bogdahn U,Schulte-Mattler W

更新日期：2006-06-30 00:00:00

abstract：:Oxytocin is one of the most potent uterotonic agents and is known to fluctuate throughout the menstrual cycle, showing an increase during sexual stimulation and arousal, with a peak during orgasm in women. To date, limited data are available on the effects of oxytocin on the regulation of uterine contractility and tra...

journal_title：European journal of medical research

authors： Müller A,Siemer J,Renner S,Hoffmann I,Beckmann MW,Dittrich R

更新日期：2006-04-28 00:00:00